Predator microbes may work against antibiotic resistant disease-causing bacteria: Study

Lead author Daniel Kadouri, Ph.D., an assistant professor of oral biology at New Jersey Dental School, and his team focused on two bacteria: Micavibrio aeruginosavorus and Bdellovibrio bacteriovorus. Dr. Kadouri says the two micro organisms were chosen because they are true predators. "They actually have to consume other bacteria in order to complete their life cycles," notes Kadouri. "They have a great ability to seek out other bacteria, invade them, grow in or on them, and kill them."

We live with bacteria all our lives

The researchers found that in a laboratory environment, M. aeruginosavorus was able to reduce populations of 57 of 89 bacteria examined. B. bacteriovorus reduced 68 forms of bacteria out of 83 tested. The bacteria effectively attacked include Klebsiella pneumoniae, a cause of lung infection; Pseudomonas aeruginosa, which can be fatal for patients suffering from the lung disorder cystic fibrosis; and Acinetobacter, which in its drug-resistant form can produce extremely hard-to-treat infections in wounds.

Kadouri hopes that one day medical practitioners can use these predator bacteria to supplement antibiotic drugs in treating life-threatening infections. "We have been living with bacteria all our lives," he reminds us. "There are bacteria in and on us, and they are a part of our ecology. When we eat yogurt and cheese, for example, we are eating bacteria." Kadouri adds that the predator bacteria he is examining are among the many bacteria in our environment that are considered harmless to humans.

A big unknown at the moment is whether predator bacteria can have the same effect on harmful microbes inside the human body as they do in the lab. It is possible that the human immune system would neutralise these bacteria before they could do their beneficial work. However, if that problem can be avoided, or solved, Kadouri is confident that a new disease-fighting tool may one day be put into use.

Source: University of Medicine and Dentistry of New Jersey-New Jersey Dental School