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Colorectal cancer trial investigates sequential versus combination chemotherapy
A Dutch phase III randomised controlled trial involving 820 patients has been done to investigate sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO).
Background
The optimum use of cytotoxic drugs for advanced colorectal cancer has not been defined. Our aim was to investigate whether combination treatment is better than sequential administration of the same drugs in patients with advanced colorectal cancer.
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