Telkom has announced that its CEO and executive director Sipho Maseko will step down on 30 June 2022. The telecoms company said the process to appoint a successor is well underway and a designated group CEO will be announced in the not too distant future.
It is possible that cooking oil prevented more looting in South Africa in the last week than the president, the ANC, the intelligence community, the army and the police combined. This, without question, says something about the versatility of the product. It says even more about the state of the state. When you are shown up by canola, you might want to revisit your strategy.ByHoward Feldman
Performance Media across Search, Social and Programmatic platforms is the single fastest growing area of digital media in South Africa. Combine that with the detailed analysis of campaign management, tagging and ad operations, and it becomes apparent that these highly specialist functions require a highly specialised unit.
The Transnet Port Terminals website has been hacked, implying that all companies under Transnet have been affected. All Transnet websites were down at the time when reporting was done for this SA Trucker article. The publication cited sources who requested to remain anonymous because they are not allowed to speak to the media.
Whether or not a person with Covid-19 develops severe disease depends a lot on how their immune system reacts to the coronavirus. But scientists still don't know why some people develop severe disease while others suffer only mild symptoms - or no symptoms at all. Now, a new study from Yale University sheds some light on the issue.
The research, which has yet to be peer reviewed and published in a journal, suggests that in patients with severe Covid, the body produces “autoantibodies”. These are antibodies that – instead of attacking the invading virus – attack the patient’s own immune system and organs.
The researchers found that people with severe Covid had autoantibodies that latched onto crucial proteins involved in recognising, alerting and clearing cells infected with the coronavirus. These proteins include cytokines and chemokines – important messengers in the immune system. This interfered with the normal immune system function, blocking antiviral defences, potentially making the disease more severe.
Links with autoimmune disorders
For many years, autoantibodies have been known to be involved in autoimmune diseases, such as rheumatoid arthritis and lupus. It is not known why some people develop these antibodies, but it is likely to be a combination of genetics and environment. Viral infections have also been linked to the onset of some autoimmune diseases.
Earlier this year, scientists reported that patients with no history of autoimmune disease developed autoantibodies after getting Covid. In these studies, the autoantibodies were found to recognise similar targets to those found in other well-known autoimmune diseases, such as proteins normally found in the nucleus of cells. Later studies discovered that people with severe Covid can also develop autoantibodies to interferons, immune proteins that play a major role in fighting viral infections.
The Yale scientists who carried out the latest study, used a new technique that screened for autoantibodies that work against thousands of the body’s proteins. They searched for autoantibodies in 170 hospitalised patients and compared them with autoantibodies found in people who suffered mild illness or asymptomatic infection, as well as people who had not been infected with the virus.
In the blood of the hospitalised patients, they found autoantibodies that could attack interferons, as well as autoantibodies that could interfere with other critical cells of the immune system such as natural killer cells and T cells. The findings showed that autoantibodies were a very common feature of severely ill Covid patients.
The Yale researchers conducted further tests in mice, which showed that the presence of these autoantibodies could make the disease worse, suggesting that these autoantibodies could contribute to the severity of Covid in humans.
Not the whole story
Though Covid patients had many autoantibodies that targeted immune system proteins, the researchers didn’t find any Covid-specific autoantibodies that could be used to distinguish severely ill Covid patients. What determines if a person is going to suffer from severe Covid depends on many things, and autoantibodies are not the whole story.
But the research suggests that people with existing autoantibodies may be at higher risk of getting severe Covid. These people may have deficiencies in their immune response during early coronavirus infection or be predisposed to making new autoantibodies that could hinder their immune response to the virus.
Researchers are increasingly focusing on the link between severe Covid and misdirected immune responses that target healthy tissues and proteins in the body. The presence of autoantibodies suggests that, for some patients, Covid could be an autoimmune disease triggered by the coronavirus. Understanding what drives the production of autoantibodies will help scientists to develop new treatments for this disease.
Scientists don’t know how long these autoantibodies last for after the infection has cleared. An important unanswered question is whether long-term damage caused by autoantibodies could explain some symptoms of long Covid.
The Conversation Africa The Conversation Africa is an independent source of news and views from the academic and research community. Its aim is to promote better understanding of current affairs and complex issues, and allow for a better quality of public discourse and conversation. Go to: https://theconversation.com/africa
About the author
Rebecca Aicheler, senior lecturer in immunology, Cardiff Metropolitan University
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