Egypt's government bonds suffered a sell-off on international debt markets after the news of the unexpected resignation, with falls between 0.6 and 1.7 cents on the dollar and larger moves by many of the country's longer-dated bonds.
State TV said Amer had stepped down "to allow others to complete the successful development process under the leadership of the president". It gave no further details.
The change came ahead of a monetary policy committee meeting on Thursday evening where analysts polled expect the overnight deposit rate to be raised by 50 basis points (bps) in order to keep inflation in check.
Egypt is also in the midst of negotiations for fresh financing from the International Monetary Fund (IMF).
Last month the IMF said Egypt needed to make "decisive progress" on fiscal and structural reform, and that greater exchange-rate variability could have helped avoid a buildup of external imbalances and smooth adjustment to economic shocks.
Egyptian finance minister Mohamed Maait said late last month that the talks had made "very good progress".
On March 21, the central bank allowed the currency to weaken to about 18.45 to the dollar from its previous level of 15.70. On Wednesday, the pound was trading at about 19.12 pounds to the dollar.
After emerging from the worst of the coronavirus-induced slowdown, Egypt's economy suffered a new blow arising from Russia's invasion of Ukraine, as investors pulled billions of dollars out of its treasury market and commodity prices surged.
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